Analysis of multiple independent RNA-seq datasets of human brain samples revealed that SLC7A2 transcripts were selectively elevated in HD patients, including GSE64810 (grade 3/4 prefrontal cortex Brodmann area 9 (BA9) [41] shown in Fig. 1D), GSE129473 (symptomatic BA9 [42]) and Al-Dalahmah et al. (single-cell RNA-seq of astrocytes from grade 3/4 cingular cortex [43]). This evidence concerns the gene SLC7A2 and Huntington disease.