We recently reported that SLC7A2 transcripts were significantly upregulated (> 15-fold increase) in human neuroblastoma SH-SY5Y cells when normal HTT was knocked out using the CRISPR–Cas9 system [6], suggesting that normal HTT may functionally repress SLC7A2 transcription and that this function could be potentially affected by muHTT. This evidence concerns the gene SLC7A2 and neuroblastoma.