SLC7A2 and Huntington disease: By examining the scRNA-seq data from postmortem caudate putamen tissue of grade 2–4 HD and matched unaffected controls (GSE152058) [44], we further noticed that there is a moderate but significant increase in SLC7A2 mRNA in astrocytes (log2FC = 0.24, FDR = 9 × 10–66).