The LASS2 protein level was negatively correlated with clinical TNM stage in both breast cancer and HCC tissues (P = 0.003 and P = 0.014, respectively) (Fig. 2B and C), and negatively correlated with distant metastasis in breast cancer (P = 0.031) (Fig. 2B). Here, CERS2 is linked to hepatocellular carcinoma.