For instance, LASS2 was found to cell proliferation and induce apoptosis in HepG2 hepatoblastoma cells (HBs) through downregulation of the NF-κB signalling pathway [5] and to suppress hepatocellular carcinoma (HCC) through upregulation of the TGF-β1-Smad4-PAI-1 axis [6]. The gene discussed is SMAD4; the disease is hepatocellular carcinoma.