CXCL8 and necrotizing enterocolitis: It was found that the proinflammatory factors interleukin-1β and interleukin-8 play an important role in the pathogenesis of NEC, and glucocorticoids significantly inhibit the proinflammatory effects of both and promote the maturation of the gastrointestinal tract while reducing the absorption of macromolecules by the intestinal mucosa and avoiding intestinal necrosis [88].