Unsupervised clustering applied to the gene effect identified a cluster of 7 genes (WARS1, IFITM3, NAMPT, PSMA2, NUP93, PSMB2, and PSMA3) that consistently decreased the fitness of AML cells after knockout (Supplementary Fig. 6F, G). The gene discussed is IFITM3; the disease is acute myeloid leukemia.