MTOR and cancer: It can be speculated that long-term mTOR blockade leads to the accumulation or exhaustion of specific proteins, which becomes limiting factor for the perturbation of local subnetworks in the GRN [87], resulting in new gene expression signatures described in the literature for dormant cancer cells, such as NR2F1, Nanog, and ZFP281 [14, 19, 23] (Fig. 3).