TIMD4 and periodontitis: Notably, Tim4+ macrophages proportions shared highly synchronized dynamic changes with CD301b+ macrophages proportions, as Tim4+ macrophages proportions gradually declined with the progression of periodontitis (14.4% on Day 0; 11.2% on Day 4, P < 0.05; 6.7% on Day 8, P < 0.01; 3.8% on Day 11, P < 0.001) (Fig. 2c, d).