HMGCR and cancer: Thus, the absence of HMGCR (and NANOG) expression in the reprogrammed clones may reflect the incomplete or partial reprogramming usually observed in cell lines covering a wide range of human cancers, including BC (Lin et al. 2008; Miyoshi et al. 2010; Mathieu et al. 2011; Corominas-Faja et al. 2013; Stricker et al. 2013).