The variability in HMGCR expression regardless of BC subtype and higher resistance to statins in luminal models was also corroborated in vitro in a panel of BC cell lines comprising representative luminal (MC-7, T47D, BT474) and TNBC models (MDA-MB-468, HCC70, MDA-MB-231, Hs578T) (Fig. 3a). The gene discussed is HMGCR; the disease is breast cancer.