ESR1 and neoplasm: Supporting our findings, HMGCR expression was shown to be associated with poor prognosis and decreased survival in BC patients, in PDX from TNBC and with more aggressive tumor characteristics such as higher histological grade, high Ki67 and ER negativity (Clendening et al. 2010; Ehmsen et al. 2019; Bjarnadottir et al. 2020).