ATP2B4 (Log2FC = 0.789; p.adj = 0.0229), SLC8A3 (Log2FC = 1.232; p.adj = 0.006), ITPR3 (Log2FC = 3.641; p.adj = 0.003), CANX (Log2FC = 1.636; p.adj = 0.002), MCUB (Log2FC = 2.907; p.adj = 1,55E-05), SARAF (Log2FC = 0.568; p.adj = 0.037) and P2RY2 (Log2FC = 2.897; p.adj = 0.005) were found to be upregulated, while NFATC4 (Log2FC = − 0.699; p.adj = 0.022) was found to be downregulated in TSC. This evidence concerns the gene P2RY2 and tuberous sclerosis.