Furthermore, NF-κB boosts the cell cycle by increasing the expression of c-myc and cyclins D3, D2, D1, and E. NF-κB transcription factors stimulates tumor associated macrophages (TAMs) in the stroma around a tumor to produce inflammatory cytokines, which decrease the maturation of DCs and inhibit the acquired immune response required for rejection of tumors [50]. This evidence concerns the gene CCND3 and neoplasm.