The typical immunophenotype of mesonephric-like carcinoma includes CD10 luminal expression; PAX8, GATA3, and TTF1 nuclear positivity, negativity, or focal positivity for ER and PR; retained MMR expression; wild-type p53 pattern; and non-diffuse p16 expression [8, 17, 20]. The gene discussed is ESR1; the disease is carcinoma.