Using human A549 (p53 wild-type) and H1299 (p53-null) NSCLC cell lines33,34, we have previously found higher intact levels of Aβ40/42 in the media of A549 than H1299 cells that was likely due, in part, to increased proteolysis of Aβ40/42 by the matrix metalloproteinase, MMP2, in H1299 cell media35. Here, TP53 is linked to non-small cell lung carcinoma.