Moreover, top-hit pathways of the not-severe set of genes are not explicitly related to ECM and not consistent between Reactome and KEGG (Reactome Susceptibility to colorectal cancer R-HSA-5083636, p adjusted = 4.131e−7, genes MUC3A/5B/12/16/17/19; KEGG Huntington’s disease hsa05016, p adjusted = 0.07103, genes REST, CREB3L4, CLTCL1, DNAH2/8/10/11). This evidence concerns the gene CREB3L4 and colorectal cancer.