While RUNX1 mutant AML is categorized to the adverse risk ELN group, PHF6MT exerted an additional negative effect on survival with RUNX1MT when compared to cases carrying these mutations alone or WT both in male and female patients (p = 3.5 × 10−18 in all; p = 6.9 × 10−15 in male; p = 9.0 × 10−4 in female; Fig. 5A, C). Here, RUNX1 is linked to acute myeloid leukemia.