In this regard, patients with dermoscopy observation indicating a high risk of MM will be additionally asked to conduct the surgical excision (tissue biopsy) followed by immunohistochemical staining for markers including S100, HMB45 and Melan A etc. for further evaluation.[6] However, tissue biopsy is invasive, painful, and likely to leave a scar on the patient's skin. Here, S100A1 is linked to Miyoshi myopathy.