Attenuating fibrosis in pancreatic ductal adenocarcinoma (PDAC) to break the physical barrier has indeed been explored as a strategy to enhance the accessibility of tumor cells to both traditional drugs and nanoparticle drugs.[22] According to previous studies and our findings, a‐PSCs play crucial roles in shaping the fibrotic microenvironment of pancreatic cancer.[4, 5] On the one hand, a‐PSCs produce abundant ECM components, such as collagen, fibronectin, and hyaluronic acid, which, combined with a‐PSCs themselves, constitute the central part of pancreatic tumor tissues. Here, FN1 is linked to familial pancreatic carcinoma.