Similar to the findings obtained in the orthotopic pancreatic cancer model, although there were no statistically significant differences in tumor size and weight between the saline and JQ1 groups (Figure 4K,L), the JQ1 treatment reduced FAP‐α, α‐SMA, and IL6 protein levels and collagen deposition in the xenografts (Figure 4M–P). This evidence concerns the gene ACTA1 and familial pancreatic carcinoma.