To test this hypothesis, we first constructed an immunocompetent orthotopic pancreatic cancer mouse model by injecting a mixture of mPSCs and luciferase‐carrying pancreatic tumor cells (KPC‐luci), which were extracted from pancreatic tumors from KPC mice (LSL‐KrasG12D/+; LSL‐Trp53fl/+; Pdx1‐Cre) and transfected with luciferase gene, into the pancreas of immunocompetent C57BL/6 mice. The gene discussed is PDX1; the disease is pancreatic neoplasm.