These findings were consistent with the results of an earlier study, which showed that BET inhibitors blocked collagen I production in a‐PSCs but did not pursue the detailed underlying mechanisms.[25] Taken together, our data demonstrate that SEs in a‐PSCs play a dominating role in shaping the highly fibrotic PDAC microenvironment, highlighting that SEs can control not only the growth of tumor cells but also the formation of tumor microenvironment in specific malignancies. The gene discussed is DNER; the disease is neoplasm.