FN1 and pancreatic ductal adenocarcinoma: Attenuating fibrosis in pancreatic ductal adenocarcinoma (PDAC) to break the physical barrier has indeed been explored as a strategy to enhance the accessibility of tumor cells to both traditional drugs and nanoparticle drugs.[22] According to previous studies and our findings, a‐PSCs play crucial roles in shaping the fibrotic microenvironment of pancreatic cancer.[4, 5] On the one hand, a‐PSCs produce abundant ECM components, such as collagen, fibronectin, and hyaluronic acid, which, combined with a‐PSCs themselves, constitute the central part of pancreatic tumor tissues.