Emerging evidence shows that β cell‐specific Gαs deficiency leads to insulin‐deficient diabetes, causes high blood glucose, reduces glucose‐stimulated insulin secretion, and decreases β cell mass.[28, 30] More importantly, Gαs deficiency in β cells causes small body size in mice,[29] which is consistent with the phenotypes observed by us in Ins2‐Tipe1BKO‐db/db mice. Here, INS is linked to diabetes mellitus.