INS and Impaired glucose tolerance: However, in Ins2‐Tipe1BKO‐db/db mice, the impaired glucose tolerance was not associated with insulin resistance, and markedly increased insulin sensitivity was observed based on their markedly acute hypoglycemic response to insulin (Figure 1H; Figure S5A, Supporting Information), with improved insulin signaling in skeletal muscle and adipose tissues (Figure S5B, Supporting Information).