Several studies report that growth hormone levels are reduced in patients with T2D owing to high blood glucose levels.[52, 53] We detected fasting insulin and growth hormone levels in Ins2‐Tipe1BKO‐db/db and Ins2‐Cre‐db/db mice at 1 month of age and found that fasting insulin and growth hormone levels were significantly reduced in Ins2‐Tipe1BKO‐db/db mice (Data not show). Here, INS is linked to type 2 diabetes mellitus.