The tumor necrosis factor (TNF)‐α‐induced protein 8‐like 1 (Tipe1) belongs to the TNF‐α‐induced protein 8 (TNFAIP8) superfamily, and the family members have fairly high sequence homology.[11, 12] Previous evidence has suggested that Tipe1 is involved in cell proliferation,[13, 14] immunomodulation,[15, 16] carcinogenesis[17, 18] and diabetes‐related diseases.[19] Although Tipe1 is highly expressed in the islets of normal mice,[11] the roles of Tipe1 in β cell functions and the development of diabetes remain largely uncharacterized. This evidence concerns the gene TNF and diabetes mellitus.