LPCAT2 and colorectal carcinoma: Specifically, chemoresistant CRC cells upon 5-fluorouracil and oxaliplatin treatments in vivo and in vitro, showed lipid droplet accumulation and sensitivity is restored upon loss of LPCAT2, supporting PC synthesis.21 Interestingly, LPCATs enzymes participate, at different levels, in the regulation of lipid droplet formation, which plays a key role in lipid droplet membrane synthesis and expansion through PC biosynthesis.46 In addition, LPC and ceramides were down-regulated in the same conditions.