Likewise, a work focused on the spatial effect of the intratumoral microbiota in cancer, reported an increase in CD11b+ and CD66b+ myeloid cells but lowered densities of CD4+ and CD8+ T-cells in bacteria-positive microniches when compared to bacteria-negative areas.5 Further work is now needed to determine whether this lowered intratumoral accumulation of IFNγ-producing CD8+ T-cells may result from a decreased immunogenicity of tumor cells. Here, CD4 is linked to cancer.