LPCAT2 and cancer: Of note, PC and PI are generally increased in CRC and have been associated with cancer development and progression.36,37 Furthermore, PS can be synthesized from PC and PE and plays an important role in mitochondrial function and apoptosis.38 LPCAT2 has been associated as an important enzyme in inflammatory cells and is up-regulated by LPS stimulation.39 Furthermore, we noticed a change in the expression of enzymes from the cytosolic phospholipase A2 (cPLA2) family that is also involved in the reacylation of the Lands cycle.