In addition, blocking lymph node egress with FTY720 or surgically removing of the tumor-draining lymph node reduced the overall antitumor activity elicited by PD-1/PD-L1 blockade in mice (Dammeijer et al., 2020; Fransen et al., 2018; Nagasaki et al., 2022). The gene discussed is CD274; the disease is neoplasm.