SH2B3 and systemic lupus erythematosus: SH2B3 has already been robustly linked to SLE by GWAS with the lead common variant (rs10774625) tagging a haplotype block that encompasses the whole of SH2B3, being a strong expression quantitative trait loci (Alcina et al., 2010; Bentham et al., 2015; Morris et al., 2016; Wang et al., 2021), and being in linkage with a relatively common missense SH2B3 variant, rs3184504 (r2 = 0.92), encoding SH2B3 W262R.