Previous bioinformatic analysis of WGS/WES in our cohort of 132 SLE patients and 97 healthy controls (HCs) revealed that 5.26% and 2.06% of patients and HCs, respectively, carried rare (minor allele frequency, MAF < 0.005) SH2B3 coding variants. Here, SH2B3 is linked to systemic lupus erythematosus.