Our recent work shows that tumor ECs undergo a mesenchymal transformation, i.e., Endo-MT, to induce Snail/Slug-dependent aberrant vascularization via HGF/c-Met–, PDGF/PDGFR-β–, and PAK4-mediated mechanisms (2, 10, 14, 38). The gene discussed is PAK4; the disease is neoplasm.