CPSF6 and viral infectious disease: Along with the global 3’ UTR shortening, significant upregulation of a large number of immune-related genes was observed in CPSF6-deficient L929 cells after viral infection compared with the controls; in contrast, ectopic expression of CPSF6 in Cpsf6-/- L929CPSF6 cells suppressed the upregulation of these genes (Fig 3H).