IFNB1 and infection: After infection with VSV-eGFP, or treatment with Poly (I:C) or Poly (dA:dT), Cpsf6-/- L929 cells also exhibited higher expression of IFNB and ISGs, but this increase was suppressed in Cpsf6-/- L929CPSF6 cells (Fig 6A and 6B).