CPSF6 and viral infectious disease: Subsequently, we defined the genes with shorter 3’ UTRs upon CPSF6 deficiency and longer 3’ UTRs upon CPSF6 restoration as the target genes of CPSF6, and finally identified 1127 target genes (Fig 3C), most of which are related to virus infection, autophagy, signal transduction, metabolism and cell proliferation, as determined using Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis (Fig 3D).