PHLDA1 and cancer: We identified only 36 genes that pass a nominal p-value threshold of 0.05 following either three or 24 hours of treatment including PHLDA1 and ANKRD2 (S12A and S12B Fig), Nominal TRZ DE genes at three hours are enriched in pathways related to transcriptional regulation in cancer and p53 signaling, while there are no pathways enriched amongst 24 hour response genes (S12C Fig).