APOB and rheumatoid arthritis: LDLR-mediated LDL-C (OR 0.835; 95%CI 0.73,0.96; P = 8.8×10−3) and APOB-mediated LDL-C (OR 1.21; 95%CI 1.04,1.40; P = 9.6×10−3) demonstrated significant associations with the risk of RA (Fig 4).