Among them, SNPs rs3736228 and rs4988321 of low-density lipoprotein receptor-related protein-5 were significantly associated with susceptibility to RA [57].Patients with RA exhibit substantially elevated levels of APOB [58], which aggravates arthritis by interacting with enolase-1 expressed on the surface of immune cells, consequently amplifying the inflammatory response [59]. Here, APOB is linked to rheumatoid arthritis.