However, when analyzing the Okada Y dataset, genetic variation in APOB-mediated LDL-C was significantly associated with RA risk (OR 1.22; 95%CI 1.08,1.36; P = 0.001), whereas this association was not observed in the Finngen dataset (OR 1.05; 95%CI 0.94,1.17; P = 0.416) (Fig 3). This evidence concerns the gene APOB and rheumatoid arthritis.