APOC3 and rheumatoid arthritis: After conducting a meta-analysis to combine all MR results, significant associations were observed between genetic variants in the HMGCR-mediated LDL-C (OR 0.77; 95%CI 0.64,0.92; P = 0.004), ABCA1-mediated TC (OR 1.69; 95%CI 1.32,2.18; P = 4×10−4), and APOC3-mediated TG (OR 0.87; 95%CI 0.77,0.98; P = 0.019) targets and the risk of RA (Fig 3).