HMGCR and osteoarthritis, knee: Notably, HMGCR-mediated LDL cholesterol, a target for statins, demonstrated a suggestive association with both overall OA of the hip or knee (OR = 0.865, 95%CI: 0.762 to 0.983, p = 0.026, q = 0.07) and knee osteoarthritis specifically (OR = 0.746, 95%CI: 0.639 to 0.871, p = 2.180×10−4, q = 0.004).