Therefore, a prediabetic state that impairs insulin-mediated inhibition of GSK3β by reduced expression of GSK3β-pSer9 may allow pathological activation of GSK3β and tau hyperphosphorylation (27, 72, 75, 85) and contribute to the increased incidence of dementia in people with prediabetes (98, 99). Here, MAPT is linked to dementia.