We examined juvenile OZRs (7–10 wk), which have excess adiposity with elevated circulating triglycerides, insulin, and corticosterone (44, 45), young adult OZRs (16–19 wk), which also have developed persistent nonfasting hyperglycemia and hypertension with impaired baroreflexes (46, 47), and older adult OZRs (28–29 wk), which also have developed fasting hyperglycemia (48, 49). This evidence concerns the gene INS and Hyperglycemia.