MAPT and metabolic syndrome: Although elevated ptau expression in the cerebral cortex of rodents and humans with MetS and ADRDs is widespread across multiple regions and cortical layers (6, 11, 12, 18, 23, 25, 73), in the medulla we observed intense and discrete staining for tau-pSer396 concentrated in the dorsal vagal complex of a young adult OZR, as reported in brains of humans with AD (79).