GSK3B and prediabetes syndrome: Therefore, a prediabetic state that impairs insulin-mediated inhibition of GSK3β by reduced expression of GSK3β-pSer9 may allow pathological activation of GSK3β and tau hyperphosphorylation (27, 72, 75, 85) and contribute to the increased incidence of dementia in people with prediabetes (98, 99).