Phosphorylation at epitopes in the PHF-1 region (Ser396) and the proline-rich middle region (Ser199,202) of the tau protein within the medulla, cortex, and hippocampus is increased in adult OZRs, other rodent models of MetS, and postmortem brains from humans with AD (18, 27, 72, 74, 78, 92). This evidence concerns the gene MAPT and Alzheimer disease.