In multivariable analysis, after controlling for race and ethnicity, goblet or signet histologic findings, tumor grade, and tumor stage, elevated CEA (HR, 2.8; 95% CI, 1.7-4.9; P < .001), elevated CA19-9 (HR, 1.5; 95% CI 1.0-2.2; P = .03), and elevated CA125 (HR, 3.2; 95% CI 2.2-4.7; P < .001) remained significantly associated with decreased OS (eTable 8 in Supplement 1). Here, CEACAM5 is linked to neoplasm.