Comparing across histologic findings, all 3 TMs were most often elevated in patients with signet ring cell histologic findings (CEA, 153 patients [69%]; CA19-9, 77 patients [43%]; and CA125, 73 patients [38%]; Kruskal-Wallis statistic, 47.4 for CEA, 34.0 for CA19-9, and 29.9 for CA125; P < .001 for each) and least likely to be elevated in Goblet cell adenocarcinoma (Figure 1D; eFigure 6, eTable 5, eTable 6, and eTable 7 in Supplement 1). Here, CEACAM5 is linked to goblet cell carcinoma.