Risk factors for peanut allergy persistence include diagnosis of atopic dermatitis at age one, sensitization to at least one tree nut/one other food/or dust mite, a low threshold for peanut reaction during an oral food challenge at age one [18••], peanut-specific IgE (sIgE) ≥ 1 kU/L at diagnosis [84], and anaphylaxis as initial reaction [85]. The gene discussed is IGHE; the disease is atopic eczema.