Endothelial cells further contribute to an inflammatory state in CKD upon endothelial activation by the uremic milieu [19], triggering the secretion of, for example, IL‐1, IL‐6, and monocyte chemoattractant protein‐1 [32], all potentiating the inflammatory response and favoring the development of CVD. The gene discussed is IL1B; the disease is chronic kidney disease.