The plasma levels of an array of cytokines (Type 1—interferon [IFN]γ, interleukin [IL]‐2, and tumor necrosis factor [TNF]α, Type 2—IL‐4, IL‐5, IL‐13, IFNs—IFNα and IFNβ), regulatory cytokines—IL‐10, IL‐25, and IL‐33 and other pro‐inflammatory cytokines—IL‐1α, IL‐1β, IL‐6, IL‐12, IL‐15, IL‐17A, IL‐3, IL‐7, granulocyte ‐colony stimulating factor, granulocyte macrophage‐colony stimulating factor, IL‐1Ra) were analyzed in COVID‐19 children and elderly patients. This evidence concerns the gene TNF and COVID-19.