Intrathecal injection of miR‐9‐enreched MSCs derived exosomes were effective in the treatment of cystitis‐induced pelvic/bladder nociception by inhibiting TLR4/NF‐κb/NLRP3 signal pathway in central nervous system of IC/BPS mice. This evidence concerns the gene NFKB1 and Bartsocas-Papas syndrome 1.