Based on the above evidence, in present study, we have focused on the neuroinflammation of IC/BPS, and explored whether miR‐9‐enriched MSCs derived exosomes alleviated neuroinflammaiton and cystitis‐induced bladder pain by inhibiting TLR4/NLRP3 pathway in interstitial cystitis mice, aiming to provide a new avenue for IC/BPS therapy. This evidence concerns the gene TLR4 and cystitis.