HMGB1 and COVID-19: Circulating levels of HMGB1 (a nuclear protein that binds to DNA and acts as an architectural chromatin‐binding factor) and NLRP3 (a protein expressed in macrophages that detects products of damaged cells such as extracellular ATP) were correlated with headache response to paracetamol and hospital stay in COVID‐19 patients [73].