Our previous study performed RNA-sequencing to identify the molecular features of PBL and the results showed that compared with DLBCL, some biological pathways were significantly downregulated in PBL, including BCR and TCR signaling pathways, whereas many pathways, such as cell adhesion molecules, calcium, and Wnt signaling pathways, were upregulated in PBL (17). This evidence concerns the gene BCR and diffuse large B-cell lymphoma.