zDHHC2 functions as a mediator of AGK palmitoylation, facilitating AGK translocation to the plasma membrane and activating the PI3K-AKT-mTOR signaling pathway in RCC. It also plays a crucial role in cell adhesion by palmitoylating CD9 and CD151, thereby regulating their expression and function. Furthermore, zDHHC2 palmitoylates CKAP4, which in turn influences its localization to the plasma membrane. Additionally, zDHHC2 has the potential to palmitoylate LCK and regulate its localization to the plasma membrane. Here, CD9 is linked to renal cell carcinoma.