EGFR and lung cancer: EGFR, a growth factor receptor critical for cell proliferation and differentiation (38), S-palmitoylation of EGFR by zDHHC1, zDHHC2, and/or zDHHC21 on Cys797 is essential for the stability, membrane localization, dimerization, and activation of this receptor and increases cell migration and anchor-independent growth in lung cancer (39).