zDHHC9/10 plays a crucial role in the palmitoylation of GLUT1 at C207, which enhances its localization to the plasma membrane and promotes a high level of glycolysis in glioblastoma. The zDHHC9-GOLGA7 complex serves as a specific palmitoyltransferase for HRAS and NRAS. Additionally, it may exhibit palmitoyltransferase activity towards the beta-2 adrenergic receptor/ADRB2, thereby regulating G protein-coupled receptor signaling. Here, HRAS is linked to glioblastoma.