As SOCS1 also harbors a nuclear localization signal and is required for activating p53-dependent senescence (59, 121, 131), it is not unlikely that SOCS1 may promote the induction of p53-dependent immune function-related genes and contribute to immune cell-mediated tumor control by inducing NK cell ligands and chemokines (Figure 2D). The gene discussed is TP53; the disease is neoplasm.