Following the seminal finding that the SOCS1 gene is repressed in hepatocellular carcinoma by promoter CpG methylation, similar epigenetic and miRNA-mediated SOCS1 loss has been reported in many cancers including, neuroblastoma, myeloid leukemias and colorectal, pancreatic, breast, prostate and ovarian cancers (24, 39–49). This evidence concerns the gene SOCS1 and ovarian cancer.