CD4 and lobular neoplasia: As shown in Figure 3, Table 3, infiltrated CD4+, CD8+ lymphocytes, and CD68+ macrophages in tubulointerstitium were increased in patients with proliferative LN compared with those with pure SLE ISN/RPS class V. The number of CD68+ macrophages in glomeruli was also increased in patients with proliferative LN, but the statistical difference was not significant.