GSTM1 and lobular neoplasia: In the majority of previous studies, several variables such as SCr, CIs, age, sex, Hb, urine protein-to-creatinine ratio (UPCR) or UPRO, LN duration, ISN/RPS classification, interstitial fibrosis, and tubular atrophy, have been identified as independent risk factors for poor treatment response in LN patients.