TNF and neoplasm: At the same time, senescent T cells with a suppressive role in the tumor microenvironment are able to promote the production of pro-inflammatory factors (TNF, IL-1b, and IL-6) and angiogenic factor, vascular endothelial growth factor A (VEGF-A) by monocytes/macrophages, which leads to renal tubulogenesis and tumor cell survival (2).