NFKB1 and cancer: For instance, cancer-related cognitive impairment (CRCI) has been observed in cancer patients during and after chemotherapy treatments from anthracyclines and platinum derivatives.(2) Chemotherapeutic agents can directly damage DNA and generate oxidants, such as reactive oxygen species (ROS), as a by-product of DNA repair.(3) Additionally, cancer drugs may dysregulate signalling pathways involved in maintaining antioxidant levels, such as MAPK and NF-κB.