For the identified candidate metabolites (kynurenine, pentadecanoate (15:0), 1-arachidonoylglycerophosphocholine*, androsterone sulfate, glycine, mannose), we further performed a manual investigation of metabolism-related SNPs for the second most common traits (osteoporosis for sarcopenia, while T2DM, BMI, smoking hypertension, CRP, IL-6, LDL, HDL for atherosclerosis and PAD). The gene discussed is IL6; the disease is osteoporosis.