In recent years, researchers have found that SOCS3 is involved in the AMPK signaling pathway, insulin resistance, adipocytokine signaling pathway, and JAK/STAT pathway, is activated/triggered by leptin signals, and plays important roles in lipid metabolism processes (Liu et al., 2014; Fang et al., 2020; Yang et al., 2020). The gene discussed is LEP; the disease is Insulin resistance.