Consequently,studies have demonstrated a negative prognosis for brain tumours, salivary gland tumours, thyroid carcinomas, melanoma, and twelve othertypes of malignancies when MCM3 expression is increased [15-19].The mean LI of cyclin D1 and ki-67 was found to be lower in the current study than the mean LI of MCM3 and MCM2 in the study groups.This may be the result of the MCM2 and MCM3 proteins, which are produced in the nucleus of a cell from the initial G1 phase onward andwhich recognize both cycling as well as non-cycling cells having proliferative capacity across the cell cycle [15-19]. This evidence concerns the gene CCND1 and melanoma.