TNFRSF1B and neoplasm: The TNF (Tumor Necrosis Factor), also known as TNFα, is a cytokine that can directly kill tumor cells and has no significant cytotoxicity to normal cells (Medler and Wajant, 2019), and induces cell survival or apoptosis by binding to two types of receptors (TNFR1 and TNFR2).