BRCA1 and neoplasm: Importantly, tumours associated with germline PVs in BRCA1 (gBRCA1m) tend to have higher histologic grades and are more likely to yield triple-negative tumours (58.1%) compared to tumours associated with germline PVs in BRCA2 (gBRCA2m) and noncarriers (34.4% and 7.5%, respectively) [9].