EGFR and adenocarcinoma: Some large studies showed an association of EGFR overexpression with younger age [31], histological type (more frequently and strongly overexpressed in squamous cell carcinomas than adenocarcinomas and adenosquamous carcinomas) [16, 44–46, 50], increasing tumour size, lymph node metastases and recurrence [6, 31, 43, 44, 48, 51].