Consistent with previous observations indicating that RNA virus infections, such as hepatitis C, SARS-CoV2, and HIV, induce an anti-apoA1 IgG response (18–20), this study confirms preliminary results suggesting that such biological signature is associated with canonical biological determinants of HIV severity, including higher viremia and lower CD4+ cell counts, which are known to be major determinants of cardiovascular complications in PLWH (37, 38). Here, CD4 is linked to Hepatitis.