In this study, injectable methacrylate gelatin (GelMA) microspheres (GM) functionalized with dopamine and hepatocyte growth factor (HGF) were fabricated to inhibit oxidative stress and inflammation at the pathogenic sites of tendinopathy, regulate the local tendon microenvironment, ameliorate ECM metabolic disorders, and prevent tendon degeneration. This evidence concerns the gene HGF and Other metabolic disease.