DRAM1 and myocardial ischemia: DRAM1 showed a significant direct interaction only with Atg7, which regulated the autophagic flow of DRAM1-Atg7-Atg12/Atg5 under the stress condition of myocardial ischemia, thereby alleviating autophagic flow and regulating the mechanism of myocardial cell protection (Wu et al., 2018) (Figure 3).