DRAM1 showed a significant direct interaction only with Atg7, which regulated the autophagic flow of DRAM1-Atg7-Atg12/Atg5 under the stress condition of myocardial ischemia, thereby alleviating autophagic flow and regulating the mechanism of myocardial cell protection (Wu et al., 2018) (Figure 3). Here, ATG7 is linked to myocardial ischemia.