Neural activity receptor-ligand facilitates signaling between lung fibroblasts and neurons, and the abnormal expression of its receptor-ligand-related genes, such as FPR1, BDKRB2, MCHR1, NMUR1, CNR2, P2RY14, and PTGER3, is observed in IPF lung fibroblasts (Nguyen et al., 2021). The gene discussed is P2RY14; the disease is idiopathic pulmonary fibrosis.