Neural activity receptor-ligand facilitates signaling between lung fibroblasts and neurons, and the abnormal expression of its receptor-ligand-related genes, such as FPR1, BDKRB2, MCHR1, NMUR1, CNR2, P2RY14, and PTGER3, is observed in IPF lung fibroblasts (Nguyen et al., 2021). This evidence concerns the gene CNR2 and idiopathic pulmonary fibrosis.