In the context of HCC, pterostilbene has proven its significance by targeting key signaling pathways involved in tumorigenesis, such as nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), tissue-type plasminogen activator (TPA)-induced matrix metalloproteinases (MMP-9), vascular endothelial growth factor (VEGF), TPA-induced protein kinase C (PKC), mitogen-activated protein kinase (MAPK), p38, PI3K, and Akt [10]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.