In Kelch‐like ECH‐associated protein 1 (KEAP1)‐mutant lung cancer, as well as other cancer cells with mutations affecting Kristen Rat Sarcoma Viral oncogene homolog (KRAS), researchers have observed significant upregulation of FSP1 as a protective response through nuclear factor erythroid 2‐related factor 2 (NRF2).33, 41. This evidence concerns the gene AIFM2 and cancer.