APP and Alzheimer disease: Impaired mitochondrial function is also a recognized change in the brains of AD patients (Wang et al., 2020) and animal models of AD (Fang et al., 2019; Demarest et al., 2020) and the evidence indicates that mitochondrial metabolism is particularly compromised in female APP/PS1 mice (Demarest et al., 2020; O’Neill et al., 2022).